Your journey, our Science

In Conversation with Our Experts – Exploring the Microbiome in the Context of Weight Management

At Azento Health, science is at the heart of everything we do. In this series, we sit down with leading experts in gut health, microbiology, and probiotics to unpack the science behind gut health, obesity, GLP-1 treatments, and the microbiome.

Prof. Bożena Cukrowska, MD, PhD

Professor of Medicine, Paediatrician, Immunologist, Microbiota Researcher, Scientific Advisor, Nordic Biotic

1. How does gut imbalance relate to metabolic health?

Changes in the composition and activity of the gut microbiota - often referred to as dysbiosis - have been studied in relation to intestinal barrier function and immune responses. Scientific literature suggests that certain microbial patterns may coincide with increased intestinal permeability and immune activation, which are observed in individuals with metabolic conditions.

2. What is the microbiome’s role in energy balance and nutrient interactions?

The microbiota can influence how our body interacts with food. Research indicates that microbial composition may affect how energy is extracted from food and how certain signaling molecules influence appetite or gut-brain communication. These dynamics are part of a larger system that supports nutritional balance.

3. What is known about short-chain fatty acids (SCFAs)?

SCFAs such as butyrate, acetate, and propionate are produced by the fermentation of fiber by gut bacteria. They have been studied for their potential roles in supporting intestinal cell nutrition, gut barrier function, and immune regulation. These natural bacterial by-products are an exciting area of research in gut and metabolic science.

4. What relevance do lactic acid bacteria have in this context?

Some lactic acid bacteria have been studied for their potential to support the integrity of the intestinal barrier and contribute to the balance of the microbiome. Although further research is needed, preliminary evidence suggests that certain strains may play a complementary role in modulating the microbiome in adults with dietary or lifestyle changes.

5. What continues to excite you about the microbiome?

Its complexity and adaptability. It responds to diet, age, environment — and holds promise for preventive health strategies. There’s still much to learn about how we can support it through lifestyle, nutrition, and supplementation.

Dr. Peter Kaufmann (ETH Zurich)

Chief Scientific Officer & Chief Operating Officer, Azento Health

1. What guided the formulation of Forte80™?

We began by reviewing areas where digestive balance is often challenged - for instance, during significant dietary shifts or structured weight management. We selected bacterial strains that have been studied for their role in microbiome resilience and GI comfort, particularly in adults undergoing metabolic interventions.

2. Why a high CFU count?

A high CFU (colony-forming units) count is important to ensure that enough live bacteria reach the gut. Forte80™ delivers 80 billion CFU per day using advanced capsule technology designed to protect the viability of the strains during digestion.

3. How were the strains chosen?

We conducted a meta-analysis of over 250 scientific studies, supported by AI-based literature mapping, to identify strains that have been studied in relation to microbiome balance and digestive adaptation. These were selected for their quality, stability, and relevance to adult gut health.

4. Can supplements support those on GLP-1 medications?

People who use GLP-1-based therapies often report changes in digestion and appetite.

5. What fascinates you about the microbiome?

The gut is incredibly dynamic - it’s not just about digestion, but about how we adapt to life changes. I see the microbiome as a key part of the future of personalized nutrition and wellness.

Jesper Gantzel

Chairman of the Board, Azento Health

1. Why support a gut-focused product in the weight management space?

Many people who are concerned about their weight report changes in their digestive system. Supporting the intestinal flora is therefore essential.

2. How do you see microbiome science intersecting with modern therapies?

We’re seeing a shift from simply managing outcomes to supporting overall biological balance. Microbiome science offers a complementary lens - not to replace medications, but to support overall well-being in an increasingly personalized healthcare landscape.

3. What potential do lactic acid bacteria have in the treatment of obesity?

I believe targeted microbiome support will become a core part of holistic care - not as a stand-alone, but as a supportive element alongside nutritional strategies, exercise, and advanced therapies like GLP-1s. The future is personalized, and the microbiome is part of that equation.

4. Why is education so important in this area?

Because the microbiome is often misunderstood. People deserve clear, science-based information - not hype. At Azento Health, we aim to provide clarity, backed by scientific integrity.

5. What inspires you most about the work?

We’re at the beginning of a new chapter in health. For me, it’s not just about selling a product - it’s about giving people tools that are grounded in science and respectful of their journey.